2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N1638
    1-Methyl-2-undecyl-4(1H)-quinolone 59443-02-6 98%
    1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC50 and Ki values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS.
    1-Methyl-2-undecyl-4(1H)-quinolone
  • HY-N1818
    Deoxysappanone B 113122-54-6 98%
    Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage.
    Deoxysappanone B
  • HY-N1838
    Dehydromaackiain 59901-98-3 98%
    Dehydromaackiain is a potent Neurogenin2 (Ngn2) promoter activator. Dehydromaackiain promotes differentiation of neural stem cells into neurons.
    Dehydromaackiain
  • HY-N1876
    Aromadendrane-4β,10α-diol 70051-38-6 98%
    Aromadendrane-4β,10α-diol is a sesquiterpene alcohol. Aromadendrane-4β,10α-diol significantly ameliorates the Aβ1-42 peptide-induced memory impairment. Aromadendrane-4β,10α-diol can be used for Alzheimer's disease (AD) research.
    Aromadendrane-4β,10α-diol
  • HY-N2034
    Dehydrodicentrine 19843-03-9 98%
    Dehydrodicentrine is an aporphine alkaloid can be isolated from the root of S. epigaea and has inhibitory effect on acetylcholinesterase (AChE) with an IC50 value of 2.98 μM.
    Dehydrodicentrine
  • HY-N2049
    20(R)-Notoginsenoside R2 948046-15-9 98%
    20(R)-Notoginsenoside R2 is an isolated notoginsenoside from Panax notoginseng.
    20(R)-Notoginsenoside R2
  • HY-N2219
    Picfeltarraegenin X 1391826-61-1 98%
    Picfeltarraenin X, a triterpenoid isolated, is an AChE inhibitor.
    Picfeltarraegenin X
  • HY-N2239
    6-Methoxykaempferol 3-O-Rutinoside 403861-33-6 98%
    6-Methoxykaempferol 3-O-Rutinoside is a natural product isolated from the herbs of Pilocarpus pennatifolius.
    6-Methoxykaempferol 3-O-Rutinoside
  • HY-N2304
    3-O-Methyl-6β-naltrexone 65150-66-5 98%
    3-O-Methyl-6β-naltrexone is a metabolite of Naltrexone.
    3-O-Methyl-6β-naltrexone
  • HY-N2317
    Di-O-demethylcurcumin 60831-46-1 98%
    Di-O-demethylcurcumin (Bisdemethylcurcumin) is an intestinal metabolite of curcumin with neuroprotective effects.
    Di-O-demethylcurcumin
  • HY-N2428
    N-(3-Methoxybenzyl)Palmitamide 847361-96-0 99.96%
    N-(3-Methoxybenzyl)Palmitamide is a promising inhibitor of FAAH for the treatment of pain, inflammation and CNS degenerative disorders.
    N-(3-Methoxybenzyl)Palmitamide
  • HY-N2433
    Paederosidic acid methyl ester 122413-01-8 99.81%
    Paederosidic acid methyl ester is a ATP‐sensitive K+ channel activator, isolated from P. scandens. Paederosidic acid methyl ester exhibits significant central analgesic activity, and enhances the threshold of pain by activating ATP‐sensitive K+ channel in the brain and spinal cord level.
    Paederosidic acid methyl ester
  • HY-N2482
    Guvacine 498-96-4 98%
    Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively.
    Guvacine
  • HY-N2550
    (+)-Coclaurine 2196-60-3 98%
    (+)-Coclaurine ((+)-(R)-Coclaurine), benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine has anti-aging activity.
    (+)-Coclaurine
  • HY-N2573
    Corydalmine 30413-84-4 98%
    Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.
    Corydalmine
  • HY-N2898
    Artanin 96917-26-9
    Artanin is a coumarin, has biological activities related to Alzheimer’s disease. Artanin exerts function including AChE inhibitory and AChE- and self-induced amyloid beta (Aβ) aggregation inhibitory activities, with IC50s of 51 μM, 98 μM, and 124 μM, respectively.
    Artanin
  • HY-N2916
    Barbinervic acid 64199-78-6 98%
    Barbinervic acid is a glutaminase inhibitor with an IC50 of 14 μM. Barbinervic acid can be used for the study of neurodegenerative diseases.
    Barbinervic acid
  • HY-N2965
    Bryonolic acid 24480-45-3 98%
    Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities.
    Bryonolic acid
  • HY-N3117
    Paeonilactone B 98751-78-1 ≥98.0%
    Paeonilactone B is a monoterpene with neuroprotective effect against oxidative stress. Paeonilactone B protects rat cortical cells against H2O2-induced neurotoxicity.
    Paeonilactone B
  • HY-N3145
    Oleonuezhenide 112693-21-7 ≥98.0%
    Oleonuezhenide, isolated from Fructus Ligustri Lucidi, exerts neuroprotective effects.
    Oleonuezhenide
Cat. No. Product Name / Synonyms Application Reactivity